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Common Signs and Symptoms of Bronchiectasis Include: Chronic cough that produces mucus Recurrent respiratory infections e. Breathlessness and wheezing General fatigue COPD is similar to bronchiectasis in that it causes frequent pneumonias, inflammation, and permanent damage to your lungs. Depending on the cause of bronchiectasis, the extent of the disease may be localised and focal or diffuse. Although the majority of individuals with bronchiectasis have impaired mucociliary clearance and excess sputum production, not all patients are persistently colonised with bacteria.
Bacterial colonisation and markers of inflammation in sputum are intermittent in most people. Patients often remain colonised with the same micro-organism during acute exacerbations as well as a stable clinical state.
The severity of airway obstruction and rate of decline in lung function may be influenced by the colonizing microorganisms. Individuals who show signs of colonization with P seudomonas aeruginosa have had more extensive disease on HRCT, greater airflow obstruction and a faster rate of decline in airflow obstruction. Haemophilus influenzae is also known to induce detrimental effects on lung function. Fig 1. Wrote the paper: QD YS. Browse Subject Areas?
Click through the PLOS taxonomy to find articles in your field. Abstract Background Bronchiectasis revealed by chest computed tomography in COPD patients and its comorbid effect on prognosis have not been addressed by large-sized studies. Results Fourteen observational studies were eligible for the study.
Conclusions The presence of bronchiectasis in patients with COPD was associated with exacerbation frequency, isolation of a potentially pathogenic microorganism, severe airway obstruction and mortality. Introduction Chronic obstructive pulmonary disease COPD is one of the leading causes of morbidity and mortality around the world [ 1 ]. Data Synthesis and Analysis The Stata version Download: PPT. Fig 1. Flowchart of process of literature review and selection.
Table 1. Characteristics of Included Studies in the Meta-analysis. Quality of Included Studies All these studies were observational cohorts, and thus there were limitations in the interpretation of causality and in methodologies.
Fig 2. Odd ratios for the association between comorbid bronchiectasis and risk for COPD exacerbations. Fig 3. Odd ratios for the association between comorbid bronchiectasis and risk for isolation of a potentially pathogenic microorganism.
Fig 4. Odd ratios for the association between comorbid bronchiectasis and risk for severe airway obstruction. Fig 5. Odd ratios for the association between comorbid bronchiectasis and risk for mortality. Discussion In this meta-analysis, we found that bronchiectasis revealed by chest CT was common in COPD patients, and these patients were more likely to have exacerbations or a longer recovery time from exacerbations.
Conclusions Implications for clinical practice This study adds to the fast growing evidence of the association between bronchiectasis and poor outcomes in COPD. Supporting Information. S1 File. S2 File. S3 File. Primary data for each figure.
References 1. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J. A genome-wide association study in chronic obstructive pulmonary disease COPD : identification of two major susceptibility loci.
Plos Genet. Mannino D M. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. View Article Google Scholar 4. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Ann Am Thorac Soc. Structural and functional co-conspirators in chronic obstructive pulmonary disease exacerbations.
Proc Am Thorac Soc. Chronic obstructive pulmonary disease and bronchiectasis. Curr Opin Pulm Med. Bronchiectasis in COPD patients. Egyptian Journal of Chest Diseases and Tuberculosis. View Article Google Scholar Prognostic value of bronchiectasis in patients with moderate to severe chronic obstructive pulmonary disease. Phenotyping of chronic obstructive pulmonary disease using the modified Bhalla scoring system for high-resolution computed tomography.
Can Respir J. Factors associated with bronchiectasis in patients with COPD. Ann Intern Med. Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease. Arch Intern Med. New strains of bacteria and exacerbation of chronic obstructive pulmonary disease. N Engl J Med. Measuring inconsistency in meta-analyses. Duval S, Tweedie R. Trim and fill: a simple funnel plot-based method of testing and adjusting for publication bias in meta-analysis.
Sadigov AS, Akhundov S. Bronchiectasis associated with COPD: does it increase the mortality rate in patients with severe disease? Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease.
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