It is a blastocyst that will attach to and implant in the lining of the uterus. Our 46 chromosomes contain about 25, genes that have to function properly to have the embryo develop successfully. I think of it like a symphony of the genes being turned on and off at specific times.
If the timing of this is off, just like an orchestra, things will go badly. Basic science studies suggest that energy function metabolism of the embryo is also a likely cause of failure, but this too cannot be practically measured in the clinical lab.
Basic science studies and our clinical experience suggest that early embryo development can be altered by our clinical and laboratory environment. It is clear that the type of follicular stimulation in an IVF cycle will impact the oocyte and embryo.
The correct use of supporting medications LH or low dose-hCG, growth hormone, androgens may be beneficial to development of the growing follicle and egg for some individuals.
However, incorrect use of these medications can be detrimental. The type of trigger shot used to prepare for egg retrieval hCG or GnRH agonist may have an impact on egg quality also, but who may benefit from which drug and to what degree there is an advantage remain unclear. As you can imagine, the laboratory environment plays a huge role in how the embryos will perform. Culture media has evolved tremendously over the last 30 years, starting from simple media adequate for most cells to the variety of high quality embryo-specific, commercially made media that we currently use.
There are several high quality culture media available that work well however, constant quality testing is essential to make sure a chosen media performs optimally. The incubators that the embryos grow in and their function are clearly a major factor. Most high quality practices are using the small bench top incubators which do a better job of maintaining the chemical environment and temperature stability for the embryos to grow in. However, these high-tech devices must be constantly monitored, as subtle changes can impact embryo performance.
Simple things like how often the embryos are evaluated, under what conditions, and the time it takes to do so can tremendously impact embryo performance. The trend is clearly towards evaluating the embryos less frequently. It should not go without saying that technical competence of the people in the laboratory is essential for good outcomes.
However, those of us who have done inspections have seen a wide array of skill levels. In ICSI intracytoplasmic sperm injection- injecting the sperm in to the egg for example: was the procedure done at the correct time?
What kind of sperm was selected? Was the sperm inserted in the correct place in the egg? How long was the oocyte egg out of the incubator? Embryo biopsy for testing the chromosomes is a very demanding technique that requires a great deal of practice and experience.
Vitrification very rapid freezing of embryos and eggs has been a huge benefit to us, but the technique is subtle and not everyone gets the same results.
Clearly, monitoring of laboratory personnel is vital to a high quality embryology laboratory. Quite honestly, the uterus is my best friend on a day-to-day basis. That is because it usually works. I say this because over the last 26 years, I have seen large numbers of sub-optimal appearing embryos make beautiful children.
They were suboptimal often because of patient parameters, but also because our treatments and our labs were less sophisticated, and the uterus rescued them. But there are clearly uterine issues that contribute to failure, some of our creation. Structural Problems. This affects her chances of success with IVF as well. On average, only about 25 percent of transferred embryos go on to result in live births of babies.
Women under 35 using their own eggs for IVF have an implantation rate of about 45 percent. Women 40 to 42 years old using their own eggs have only about a 15 percent chance of implantation. Older women who use donor eggs, which are donated by younger women, have success rates with IVF that are nearly the same as those of younger women.
Egg quality is all-important to having healthy embryos, and younger eggs usually have better quality. Especially if a woman is over 37 or has higher FSH levels she may not produce enough eggs to result in a number of embryos for screening and potential implantation. Chances are higher that IVF will fail when this happens. Your reproductive endocrinologist will evaluate what happened and may make changes to your fertility medications for the next IVF cycle.
One of the major factors in IVF failure is chromosomal abnormalities in the embryo. This is true for all human embryos, whether naturally conceived or developed in the embryology lab. These abnormalities are the reason behind most miscarriages as well as failure to implant in an IVF cycle. Studies have shown that starting in their 30s, as women age, the incidence of choromosomal abnormalities in their eggs begins to increase. Many treatments are used commonly to help reduce the rate of implantation failure.
Some of the suitable treatments are:. We make sure that all the treatments are done properly which will help to understand how your body reacts. You will get enough information about all the symptoms as well. You can rely easily upon the treatments that we serve to make the procedures successful. You have put lots of efforts into preparing this wonderful material! It helps lots of people! Useful information. I am very happy to read this. Thanks for giving us this useful information.
Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Book An Appointment. Home » Blogs » Why do blastocyst not implant Why do blastocyst not implant? Symptoms of unsuccessful implantation Implantation usually causes changes in the tendency to smell, increased sensitivity of breasts, and slight abdominal cramping. Reasons for the failure of blastocyst implantation Here are some reasons behind the failure of blastocyst implantation: 1.
Transplantation of embryos Sometimes, the embryo that has been fertilized successfully, might not be implanted into the uterus effectively. The quality of the Embryo The major reason why an IVF cycle is not successful is because of the quality of the embryo.
Chromosomal issues One of the major factors in unsuccessful IVF is chromosomal abnormalities in the embryo. Lifestyle factor Many fertility clinics insist women quit smoking at least 3 months before starting IVF treatment. What happens after Blastocyst Transfer? Are Blastocyst Transfers More Successful? What happens when the blastocyst does not implant? Implantation failure can be treated Many treatments are used commonly to help reduce the rate of implantation failure.
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